USMLE Step 2 CK (Clinical Knowledge) tests your ability to apply medical knowledge and clinical science to patient care under supervision, with an emphasis on health promotion and disease prevention. It is reported as a three-digit score.
CliniQuiz.AI generates clinical-vignette practice questions aligned to the Step 2 CK blueprint across the major disciplines and organ systems:
Internal medicine, surgery, and pediatrics
Obstetrics & gynecology and psychiatry
Diagnosis, management, and next-best-step reasoning
Screening, prevention, and patient safety
Each question includes a thorough explanation, and the AI tutor helps you reason through diagnosis and management step by step. Try a free sample quiz below—no sign-up needed.
Sample Questions
A 58-year-old man comes to the clinic for a follow-up appointment after an upper gastrointestinal endoscopy. He has a 15-year history of gastroesophageal reflux disease, which he has managed with over-the-counter antacids and intermittent famotidine. He reports occasional heartburn but denies dysphagia, odynophagia, nausea, vomiting, or weight loss. He has a 20-pack-year smoking history and drinks 2 to 3 beers on weekends. His BMI is 31 kg/m2. Upper endoscopy performed last week revealed a 3-cm segment of salmon-colored mucosa extending proximally from the gastroesophageal junction. Biopsy of this area shows columnar epithelium with interspersed goblet cells and no evidence of dysplasia. Which of the following is the most appropriate next step in management for this patient?
Refer the patient for laparoscopic Nissen fundoplication
Initiate a daily proton pump inhibitor and schedule repeat endoscopy in 3 to 5 years
Initiate a daily proton pump inhibitor and schedule repeat endoscopy in 6 to 12 months
Schedule endoscopic radiofrequency ablation
Advise continuing on-demand antacid therapy and schedule repeat endoscopy in 3 to 5 years
A 48-year-old man presents to the emergency department with a 1-week history of nausea, early satiety, postprandial vomiting, and dull epigastric pain. Five weeks ago, he was hospitalized for severe acute pancreatitis secondary to alcohol use disorder. He was discharged after 10 days and had been doing well until his current symptoms began. His temperature is 37.1 C (98.8 F), blood pressure is 122/78 mm Hg, and pulse is 88/min. Physical examination reveals a palpable, tender fullness in the epigastric region. Laboratory studies show a leukocyte count of 8,500/mm3, serum total bilirubin of 1.0 mg/dL, and serum lipase of 110 U/L. A CT scan of the abdomen with intravenous contrast demonstrates an 8-cm, well-circumscribed, round fluid collection with a thick enhancing wall adjacent to the posterior wall of the stomach. There is no gas within the fluid collection. Which of the following is the most appropriate next step in management?
Intravenous broad-spectrum antibiotics
Percutaneous catheter drainage
Open surgical cystogastrostomy
Expectant management with repeat imaging in 3 months
Endoscopic drainage into the stomach
A 72-year-old woman presents to the emergency department with a 5-day history of severe, throbbing right-sided headaches. She also reports pain in her jaw when chewing meat, which resolves when she stops eating. Earlier today, she experienced a shadow falling over her right eye that lasted for 10 minutes before her vision returned to normal. Her past medical history is significant for hypertension and osteoarthritis. Her temperature is 37.6 C (99.7 F), blood pressure is 138/86 mm Hg, and pulse is 82/min. Physical examination reveals a tender, thickened right temporal artery with an absent pulse. Visual acuity is 20/20 in both eyes. Laboratory studies show an erythrocyte sedimentation rate of 95 mm/hr. Which of the following is the most appropriate next step in the management of this patient?
Perform a temporal artery biopsy
Administer intravenous heparin
Obtain magnetic resonance imaging of the brain
Prescribe oral carbamazepine
Initiate high-dose systemic glucocorticoids
A 74-year-old woman comes to the emergency department due to a severe, throbbing right-sided headache for the past week. She also reports pain in her jaw muscles that worsens when chewing her meals. This morning, she experienced a sudden, painless loss of vision in her right eye that lasted for 15 minutes before fully resolving. She has a history of hypertension and osteoarthritis. Her temperature is 37.8 C (100 F). Physical examination reveals a prominent, tender right temporal artery with decreased pulsation. Laboratory studies show an erythrocyte sedimentation rate of 95 mm/h. Which of the following is the most appropriate next step in management?
Initiate dual antiplatelet therapy
Prescribe oral carbamazepine
Administer intravenous methylprednisolone
Perform a temporal artery biopsy
Order magnetic resonance angiography of the head and neck
A pediatric cardiologist is interested in investigating a potential association between maternal use of a newly approved over-the-counter herbal supplement for morning sickness and the development of a rare congenital heart defect, Ebstein anomaly. The incidence of this anomaly in the general population is approximately 1 in 20,000 live births. The cardiologist identifies 40 infants diagnosed with Ebstein anomaly at a tertiary care children's hospital over the past 10 years. For comparison, the researcher selects 120 healthy infants without congenital heart defects born at the same hospital during the same time period. The mothers of all the infants are contacted and asked to complete a detailed questionnaire regarding their use of the herbal supplement during the first trimester of pregnancy. Which of the following is the most appropriate measure of association for this study design?